Alveolar epithelial cell type II as main target of SARS-CoV-2 virus and COVID-19 development via NF-Kb pathway deregulation: A physio-pathological theory

The Corona Virus Disease (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) requires a rapid solution and global collaborative efforts in order to define preventive treatment strategies. One of the major challenges this disease is high number patients needing advanced respiratory support due Distress (ARDS) as lung – although not exclusive target virus. molecular mechanisms, pathogenic drivers cell type(s) SARS-CoV-2 infection are still poorly understood, but development “hyperactive” immune response proposed play role evolution it envisioned cause morbidity mortality. Here we propose theory which main targets for Type II Alveolar Epithelial Cells clinical manifestations syndrome direct consequence their involvement. We existence vicious cycle once alveolar damage starts AEC cells, inflammatory state supported macrophage pro-inflammatory polarization (M1), cytokines release activation NF-?B pathway. If confirmed, future therapeutic can be directed cells associated with dysfunction currently available